Morbus Crohn

Mit dem Pilzgift Canditoxin dezimiert der 'harmlose' Candida albicans-Pilz die guten Bakterien der Darmflora und schädigt genau jene IgA-Antikörper, die an der Reparatur der Darmschleimhaut beteiligt sind. Mit Hilfe der Hyphen kann der Pilz dann tief in das Gewebe eindringen. Dies ist der Wirkmechanismus bei Krankheiten wie Morbus Crohn und dergl..

Morbus Crohn 2024: recent studies have shifted towards host genetics and host-fungal interactions. The mycobiota is a vital component of the gastrointestinal microbial community and plays a significant role in immune regulation. Among fungi, Candida species, particularly Candida albicans (C. albicans), have been extensively studied due to their dual role as gut commensals and invasive pathogens. Recent findings indicate that various strains of C. albicans exhibit considerable differences in virulence factors, impacting IBD's pathophysiology. Intestinal fungal dysbiosis and antifungal mucosal immunity may be associated to IBD, especially Crohn's disease (CD)